83-85-2
83-85-2
Chemical Structure
Fuscin
- CAS. Nr.: 83-85-2
- Formula:C15H16O5
- Molecular Weight:276.28
IUPAC Name: 5-hydroxy-4,8,8-trimethyl-9,10-dihydro-2H,4H-pyrano[4,3-f]chromene-2,6(8H)-dione
InChIKey: OSJKAGRXDVEZQO-UHFFFAOYSA-N
SMILES: O=C1C=C2C(C(C)O1)=C(O)C(C3=C2CCC(C)(C)O3)=O
Biological Activity: Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor[1][2][3].
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Fuscin | Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor. | |||||||||||||||||||||
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References
- [1]. K Yoganathan, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J Nat Prod. 2003 Aug;66(8):1116-7. [Content Brief]
- [2]. K S Cheah. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria. Biochim Biophys Acta.1972 Jul 12;275(1):1-9. [Content Brief]
- [3]. P M Vignais, et al. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta. 1973 Dec 14;325(3):357-74. [Content Brief]
