10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum

  • J Nat Prod. 2003 Aug;66(8):1116-7. doi: 10.1021/np030146m.
K Yoganathan  1 ,  Christine Rossant ,  Siewbee Ng ,  Yicun Huang ,  Mark S Butler ,  Antony D Buss
Affiliations
  • 1. MerLion Pharmaceuticals, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240.
PMID: 12932138 DOI: 10.1021/np030146m
Abstract

Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one known compound, fuscin (3), have been isolated from the soil fungus Oidiodendron griseum. These compounds were found to compete effectively with macrophage inflammatory protein (MIP)-1 alpha for binding to human CCR5, an important anti HIV-1 target that interferes with HIV entry into cells. The structures of these compounds were elucidated by spectroscopic methods.

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