Dihydromaniwamycin E
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses.
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- CAS. Nr.: 3033567-35-7
- Formel: C10H22N2O2
- Molecular Weight:202.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Influenza, SARS-CoV-2[1]
In Vitro
Dihydromaniwamycin E shows an inhibitory effect against influenza (H1N1) virus infection in MDCK cells by a plaque assay, exhibiting an IC50 of 25.7 μM[1].
Dihydromaniwamycin E displays antiviral activity against SARS-CoV-2, the causative agent of COVID-19 infection, in 293TA cells, exhibiting an IC50 of 19.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 3033567-35-7
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Molecular Weight 202.29
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Formel C10H22N2O2
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SMILES
CCCCCC/[N+]([O-])=N/[C@@H]([C@@H](O)C)C
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Structure Classification
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Initial Source
Streptomyces sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dihydromaniwamycin E Related Classifications
HY-N10604 Related Classifications
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