country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-182320

Copy Link Print Information

DRL-17822

Name: DRL-17822
Brand: MedChemExpress
SKU: HY-182320
Availability: PreOrder

DRL-17822 is a selective cholesteryl ester transfer protein (CETP) inhibitor. DRL-17822 increases high-density lipoprotein levels. The exposure of DRL-17822 nanocrystal formulation increases significantly after a high-fat breakfast. The exposure of DRL-17822 in the fasted state is higher than that of its nanocrystal formulation. DRL-17822 can be used in the research of type II hyperlipidemia and atherosclerotic cardiovascular disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 898911-09-6
Formel: C₃₀H₃₁F₆N₇
Molecular Weight:603.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DRL-17822 Chemical Structure

CAS. Nr.: 898911-09-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

DRL-17822 does not cross Caco-2 cell monolayers in measurable amounts, and may moderately inhibit recombinant human CYP3A4^[1].
DRL-17822 is highly lipophilic, water-insoluble, and extensively bound to plasma proteins across species^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DRL-17822 (10 mg/kg; i.v.; single dose) is hardly excreted in urine but shows moderate fecal excretion in male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male)^[1]
Dosage:

10 mg/kg
Administration:

i.v.; single dose
Result:

Recovered approximately 0.004% of the dose in urine within 24 hours.
Recovered approximately 12.5% of the dose in feces within 24 hours.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS. Nr. 898911-09-6
Molecular Weight 603.60
Formel C₃₀H₃₁F₆N₇
SMILES

FC(F)(C1=CC(CN(CC2=CC3=C(N=C2N(CC4CC4)CC5CC5)C(C)=CC=C3)C6=NN(C)N=N6)=CC(C(F)(F)F)=C1)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kruithof AC, et al. Effect of Food on the Pharmacokinetics of 2 Formulations of DRL-17822, a Novel Selective Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Males. Clin Pharmacol Drug Dev. 2019;8(8):1042-1052. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen