DSG-PEG2000-CRPPR

DSG-PEG2000-CRPPR is composed of three covalently linked components: 1. DSG (distearoylglycerol) : Lipid anchoring group-a diacylglycerol with two saturated C18 chains; provides strong membrane rigidity and sustained nanoparticle stability, suitable for applications requiring prolonged circulation time. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. CRPPR peptide: Targeting/functional ligand-the CRPPR peptide is a cardiac homing peptide that specifically targets cardiac endothelial cells by binding to cysteine-rich protein 2 (CRIP-2) receptors and can cross the intact cardiac endothelial layer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .