Med1 - mediator complex subunit 1 Gene

Also Known as PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19014

Summary

Enables several functions, including promoter-specific chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Med1 Products (5)

mRNA Protein Name
NM_001080118.1 NP_001073587.1 mediator of RNA polymerase II transcription subunit 1 isoform 3
NM_001361950.1 NP_001348879.1 mediator of RNA polymerase II transcription subunit 1 isoform 4
NM_001361951.1 NP_001348880.1 mediator of RNA polymerase II transcription subunit 1 isoform 5
NM_013634.2 NP_038662.2 mediator of RNA polymerase II transcription subunit 1 isoform 1
NM_134027.2 NP_598788.2 mediator of RNA polymerase II transcription subunit 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
15681609 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11724781 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
12446761 MGI
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
9325263 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22323595 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9325263 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15340084 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
9325263 MGI
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
16723356 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of G0 to G1 transition IMP
IMP: Inferred from mutant phenotype
17438330 MGI
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
11724781 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10747854 MGI
acts upstream of or within animal organ regeneration IMP
IMP: Inferred from mutant phenotype
17438330 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
10882104 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IMP
IMP: Inferred from mutant phenotype
17438330 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within enucleate erythrocyte development IMP
IMP: Inferred from mutant phenotype
21098667 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IMP
IMP: Inferred from mutant phenotype
15647257 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
17132730 MGI
involved in erythrocyte development IMP
IMP: Inferred from mutant phenotype
11724781 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
12037571 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10882104 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
16324150 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14500757 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
15647257 MGI
involved in lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
11724781 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
14500757 MGI
involved in mRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16723356 MGI
acts upstream of or within mammary gland branching involved in pregnancy IMP
IMP: Inferred from mutant phenotype
15647257 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: Inferred from mutant phenotype
15647257 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15843544 MGI
involved in megakaryocyte development IMP
IMP: Inferred from mutant phenotype
11724781 MGI
acts upstream of or within monocyte differentiation IMP
IMP: Inferred from mutant phenotype
16324150 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
10882104 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16723356 MGI
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
16723356 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16723356 MGI
acts upstream of or within peroxisome proliferator activated receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15150259 MGI
acts upstream of or within positive regulation of G0 to G1 transition IMP
IMP: Inferred from mutant phenotype
17438330 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10882104 MGI
acts upstream of or within positive regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
17438330 MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20351249 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11724781 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17827210 MGI
acts upstream of or within positive regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18339625 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
16828057 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9325263 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10882104 MGI
acts upstream of or within regulation of vitamin D receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16324150 MGI
involved in retinal pigment epithelium development IMP
IMP: Inferred from mutant phenotype
11724781 MGI
acts upstream of or within thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
10882104 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
11724781 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of mediator complex IDA
IDA: Inferred from direct assay
12093747 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15150259 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 1

  • PPAR-binding protein

  • Ppar binding protein

  • TR-interacting protein 2

  • peroxisome proliferator-activated receptor-binding protein

  • thyroid hormone receptor-associated protein complex 220 kDa component

  • thyroid receptor-interacting protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N10508 Calcitroic acid Ligand 85.0% Unkown
HY-N10508S Calcitroic acid-13C Ligand / Unkown
HY-RS08184 MBD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08278 MED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18247 Med1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19616 Mbd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22462 Cwc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24727 Med1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Med1 NCBI NCBI:5469