Neto1 - neuropilin (NRP) and tolloid (TLL)-like 1 Gene

Also Known as Btcl1; C130005O10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 246317

Summary

Enables ionotropic glutamate receptor binding activity. Involved in memory; regulation of long-term neuronal synaptic plasticity; and visual learning. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located in excitatory synapse and postsynaptic density membrane. Is integral component of postsynaptic density membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; metencephalon lateral wall; and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Apr 2022]

Neto1 Products (2)

mRNA	Protein	Name
NM_001360910.1	NP_001347839.1	neuropilin and tolloid-like protein 1 isoform 2
NM_144946.5	NP_659195.3	neuropilin and tolloid-like protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	21734292	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19243221	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in anterograde axonal transport of neurotransmitter receptor complex	IDA IDA: Inferred from direct assay	28680963	MGI
involved in anterograde axonal transport of neurotransmitter receptor complex	IMP IMP: Inferred from mutant phenotype	28680963	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	19243221	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	26720915	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	26720915	MGI
acts upstream of or within positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21734292	MGI
acts upstream of or within receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	21734292	MGI
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	19243221	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	26720915	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IMP IMP: Inferred from mutant phenotype	26720915	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	19243221	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	28680963	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	28680963	MGI
located in excitatory synapse	IDA IDA: Inferred from direct assay	19243221	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19243221	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19243221	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	19243221	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19243221	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	19243221	MGI
is active in postsynaptic density membrane	EXP EXP: Inferred from Experiment	19243221	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	19243221	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	19243221	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	19243221	MGI
located in synapse	IDA IDA: Inferred from direct assay	21734292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuropilin and tolloid-like protein 1	brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

Neto1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Neto1	Q8R4I7	Dlg4	Mus musculus	Q62108	Y2H	19243221
Intra	Neto1	Q8R4I7	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	19243221
Cross	Neto1	Q8R4I7	DLG4	Homo sapiens	P78352	Anti Bait CoIP	19243221
Cross	Neto1	Q8R4I7	Grin2b	Rattus norvegicus	Q00960	Anti Bait CoIP	19243221
Cross	Neto1	Q8R4I7	Grin2a	Rattus norvegicus	Q00959	Anti Bait CoIP	19243221
Cross	Neto1	Q8R4I7	Grin2a	Rattus norvegicus	Q00959	Anti Tag CoIP	19243221

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09213	NETO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20064	Neto1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26568	Neto1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Neto1	NCBI	NCBI:81832