GBP1 - guanylate binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2633

About GBP1

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,052,319-89,065,208 (from NCBI)

This gene has 9 transcripts (splice variants), 134 orthologues and 10 paralogues. Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues.

Summary

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GBP1 Products (1)

mRNA Protein Name
NM_002053.3 NP_002044.2 guanylate-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables G protein activity IDA
IDA: Inferred from direct assay
7512561 GOA
enables GDP binding IDA
IDA: Inferred from direct assay
10676968 GOA
enables GDP phosphatase activity IDA
IDA: Inferred from direct assay
7512561 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
10676968 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
7512561 GOA
enables Hsp90 protein binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables actin binding IDA
IDA: Inferred from direct assay
24337748 GOA
enables cytokine binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16511497 GOA
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
32510692 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21151871 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10676968 GOA
enables spectrin binding IPI
IPI: Inferred from physical interaction
24337748 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
17266443 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17266443 GOA
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
17266443 GOA
involved in cytolysis in another organism IDA
IDA: Inferred from direct assay
31268602 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
31268602 GOA
involved in defense response to protozoan IDA
IDA: Inferred from direct assay
31268602 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
29144452 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in negative regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in non-canonical inflammasome complex assembly IDA
IDA: Inferred from direct assay
31268602 GOA
involved in positive regulation of pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
31268602 GOA
involved in protein localization to vacuole IDA
IDA: Inferred from direct assay
21151871 GOA
involved in regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
24337748 GOA
involved in regulation of protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
24337748 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17266443 GOA
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
21151871 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17266443 GOA
is active in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
29144452 GOA
located in cytosol IDA
IDA: Inferred from direct assay
24337748 GOA
is active in symbiont cell surface IDA
IDA: Inferred from direct assay
29144452 GOA
is active in vesicle membrane IDA
IDA: Inferred from direct assay
29144452 GOA
located in vesicle membrane IDA
IDA: Inferred from direct assay
21151871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP1 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (19 - 282)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (284 - 580)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 1

  • GBP-1

GBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GBP1 P32455 GBP4 Homo sapiens Q96PP9
BiFC
21151871
Intra
GBP1 P32455 GBP4 Homo sapiens Q96PP9
Anti Tag CoIP
21151871
Intra
GBP1 P32455 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
33961781
Intra
GBP1 P32455 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
28514442
Intra
GBP1 P32455 GBP3 Homo sapiens Q9H0R5
BiFC
21151871
Intra
GBP1 P32455 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
21151871
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
GMS
16511497
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
Crosslink
22607347
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
Anti Tag CoIP
21151871
Intra
GBP1 P32455 GBP2 Homo sapiens P32456
Anti Tag CoIP
21151871
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
BiFC
21151871
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
Y2H
21151871
Intra
GBP1 P32455 GBP2 Homo sapiens P32456
Anti Tag CoIP
33961781
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
GMS
22059445
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
Y2H
22607347
Intra
GBP1 P32455 GBP2 Homo sapiens P32456
BiFC
21151871
Intra
GBP1 P32455 GBP2 Homo sapiens P32456
Anti Tag CoIP
28514442
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
GMS
22607347
Intra
GBP1 P32455 GBP1 Homo sapiens P32455
X-Ray Diffraction
16511497
Intra
GBP1 P32455 GBP5 Homo sapiens Q96PP8
Anti Tag CoIP
33961781
Intra
GBP1 P32455 GBP5 Homo sapiens Q96PP8
BiFC
21151871
Intra
GBP1 P32455 GBP5 Homo sapiens Q96PP8
Anti Tag CoIP
21151871
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GBP1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75172 GBP1 Protein, Human (HEK293, His) AAA35871.1 (M1-C589) ≥ 95%, as determined by reducing SDS-PAGE.

GBP1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83185 GBP1 Antibody (YA2930) WB, IHC-F, IHC-P, ICC/IF Human
HY-P83185A GBP1 Antibody (YA2930)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Pseudopseudohypoparathyroidism

  • PPHP

  • Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

  • Normocalcemic Pseudohypoparathyroidism

  • Aho-Pphp Syndrome

  • Albright Hereditary Osteodystrophy-Pphp Syndrome

  • Pseudohypoparathyroidism
Ulceroglandular Tularemia
Congenital Toxoplasmosis

  • Toxoplasmosis, Congenital

  • Mother-To-Child Transmission Of Toxoplasmosis

  • Toxoplasma Embryofetopathy

  • Toxoplasma Embryopathy

  • Toxoplasmosis - Congen.

  • Toxoplasmosis Congenital
Central Nervous System Tuberculosis

  • Intracranial Tuberculoma

  • Tuberculoma Of Brain

  • Tuberculosis Of Meninges And Central Nervous System

  • Tuberculous Abscess Of Brain

  • Tuberculoma, Intracranial

  • Tuberculosis, Central Nervous System
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-12929 NSC756093 99.58% Unkown
HY-RS05307 GBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24149 Gbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP1 RGD RGD:1311877
Others GBP1 NCBI