Map3k1 - mitogen-activated protein kinase kinase kinase 1 Gene

Also Known as Mekk; MEKK1; MAPKKK1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26401

Summary

Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including JNK cascade; eyelid development in camera-type eye; and positive regulation of actin filament polymerization. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast Cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map3k1 Products (1)

mRNA	Protein	Name
NM_011945.3	NP_036075.2	mitogen-activated protein kinase kinase kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	14967141	MGI
enables MAP kinase kinase activity	EXP EXP: Inferred from Experiment	9065412	MGI
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	25224220	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10523642	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of or within apoptotic mitochondrial changes	IMP IMP: Inferred from mutant phenotype	15882989	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	12941696	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	23201579	MGI
acts upstream of or within eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	23201579	MGI
acts upstream of or within morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	25224220	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	10523642	MGI
acts upstream of or within positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	12941696	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12941696	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12941696	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	12941696	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
part of filamentous actin	IDA IDA: Inferred from direct assay	25224220	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 1	MAPK/ERK kinase kinase 1 MEK kinase 1

Recombinant Map3k1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P700593	MAP3K1 Protein, Mouse (His)	P53349 (Q1216-W1493)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-RS08046	MAP3K1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17349	Map3k1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23803	Map3k1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k1	NCBI	NCBI:4214