SERPINA4 - serpin family A member 4 Gene

Also Known as KAL; KST; PI4; KLST; PI-4; kallistatin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5267

About SERPINA4

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,561,442-94,569,906 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 36 paralogues. Biased expression in liver (RPKM 98.1), gall bladder (RPKM 28.7) and 2 other tissues.

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA4 Products (3)

mRNA Protein Name
NM_001289032.2 NP_001275961.1 kallistatin isoform 1
NM_001289033.2 NP_001275962.1 kallistatin isoform 2 precursor
NM_006215.4 NP_006206.2 kallistatin isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA4 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (54 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

kallistatin

  • kallikrein inhibitor

SERPINA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SERPINA4 P29622 FKBP14 Homo sapiens Q9NWM8
Anti Tag CoIP
33961781
Intra
SERPINA4 P29622 FKBP14 Homo sapiens Q9NWM8
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINA4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71143 Serpin A4 Protein, Human (HEK293, His) P29622 (Q21-P427) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cerebral Hemisphere Lipoma

  • Lipoma Of The Cerebral Hemisphere
Corpus Callosum Lipoma

  • Lipoma Of The Corpus Callosum

  • Lipoma Of Corpus Callosum
Pituitary Adenoma 2, Growth Hormone-Secreting

  • PITA2

  • Acromegaly Due To Pituitary Adenoma 2

  • Acromegaly, X-Linked

  • Growth Hormone Secreting Pituitary Adenoma 2

  • Pituitary Adenoma, Growth Hormone-Secreting, 2

  • Pituitary Adenoma 2, Gh-Secreting

  • Gh-Secreting Pituitary Adenoma 2

  • X-Linked Acromegaly

  • Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12700 SERPINA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26348 Serpina4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SERPINA4 VGNC VGNC:68836
Bos taurus SERPINA4 VGNC VGNC:34467
Rattus norvegicus SERPINA4 RGD RGD:708581
Canis familiaris SERPINA4 VGNC VGNC:46025
Others SERPINA4 NCBI