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Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 59323

About Erbb4

Primary_assembly 9: 69,531,481-70,596,595 reverse strand.mRatBN7.2:CM026982.1

This gene has 4 transcripts (splice variants), 227 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Brain (RPKM 139.1), Kidney (RPKM 128.9) and 5 other tissues.

Summary

Predicted to enable several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including animal organ development; positive regulation of GABAergic synaptic transmission; and positive regulation of glucose import. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Colocalizes with inhibitory synapse. Used to study visual epilepsy. Biomarker of congestive heart failure; median neuropathy; radiculopathy; and schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Erbb4 Products (1)

mRNA	Protein	Name
NM_021687.2	NP_067719.2	receptor tyrosine-protein kinase erbB-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables neuregulin receptor activity	IDA IDA: Inferred from direct assay	26027736	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15219672	RGD

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	26027736	RGD
involved in cellular response to L-glutamate	IEP IEP: Inferred from expression pattern	28350885	RGD
involved in cellular response to acetylcholine	IEP IEP: Inferred from expression pattern	28350885	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21186272	RGD
involved in mammary gland development	IEP IEP: Inferred from expression pattern	10653587	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	30206770	RGD
involved in multicellular organismal response to stress	IEP IEP: Inferred from expression pattern	27133902	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14654373	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	16740635	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15355992	RGD
involved in positive regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	30206770	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17545485	RGD
involved in positive regulation of phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19191103	RGD
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17521572	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	27133902	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	15385548	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	17459743	RGD
involved in response to stress	IEP IEP: Inferred from expression pattern	34189720	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	27209698	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18184445	RGD
involved in surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	17545485	RGD
involved in synapse maturation	IMP IMP: Inferred from mutant phenotype	17521571	RGD
involved in telencephalon development	IEP IEP: Inferred from expression pattern	12571115	RGD

Cellular Component GO Annotation	Evidence	Verweise	Source
located in caveola	IDA IDA: Inferred from direct assay	10381889	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19793984	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	18819924	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16859650	RGD
is active in plasma membrane	IDA IDA: Inferred from direct assay	26027736	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17521571	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15219672	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb4 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB4

PTKc_HER4

0
300
600
900
1200
1308 a.a.

Protein Preferred Names	Protein Names
receptor tyrosine-protein kinase erbB-4	c-erbB-4 proto-oncogene-like protein c-ErbB-4 receptor tyrosine kinase v-erb-a erythroblastic leukemia viral oncogene homolog 4 v-erb-b2 avian erythroblastic leukemia viral oncogene 4

Recombinant Erbb4 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P73036	HER4 Protein, Rat (HEK293, Fc)	Q62956-1 (Q26-P651)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73037	HER4 Protein, Rat (HEK293, His)	Q62956-1 (Q26-P651)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-13272	Dacomitinib		99.74%	Yes

Pre-clinical Phase

Bioactive Molecules (20)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B0793	AZ-5104	Inhibitor	99.91%	Unkown
HY-N0353	Curdione	Inhibitor	99.80%	Unkown
HY-168438	ERBB agonist-1		99.16%	Unkown
HY-18609	PD158780	Inhibitor	99.47%	Unkown
HY-15375	Allitinib	Inhibitor	98.88%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-13427	Allitinib tosylate	Inhibitor	99.54%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	96.78%	Unkown
HY-112420	EGFR/ErbB-2-IN-2	Inhibitor	99.45%	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	Unkown
HY-RS04472	ERBB4 Human Pre-designed siRNA Set A		/	Unkown
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	Unkown
HY-E70715	ERBB2 775YVMA776 Recombinant Human Active Protein Kinase		/	Unkown
HY-B0793S1	AZ-5104-d2	Inhibitor	/	Unkown
HY-13272S3	Dacomitinib-d10		/	Unkown
HY-175809	SRT6	Inhibitor	/	Unkown
HY-RS04473	Erbb4 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04474	Erbb4 Rat Pre-designed siRNA Set A		/	Unkown
HY-174565	Human NRG3 mRNA		/	Unkown
HY-174671	Human HBEGF mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb4	NCBI	NCBI:2066