TCF21 - transcription factor 21 Gene

Also Known as POD1; bHLHa23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6943

About TCF21

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:133,889,113-133,895,537 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 13 paralogues. Broad expression in placenta (RPKM 32.6), spleen (RPKM 25.0) and 15 other tissues.

Summary

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

TCF21 Products (2)

mRNA Protein Name
NM_003206.4 NP_003197.2 transcription factor 21
NM_198392.3 NP_938206.1 transcription factor 21

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12493738 GOA
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
12493738 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12493738 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
12493738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF21 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (80 - 132)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

transcription factor 21

  • capsulin

TCF21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
TCF21 O43680 MYOD1 Homo sapiens P15172
Validated Y2H
32296183
Intra
TCF21 O43680 MYOD1 Homo sapiens P15172
Y2H Array
32296183
Intra
TCF21 O43680 MYOD1 Homo sapiens P15172
Y2H Prey Pooling
32296183
Intra
TCF21 O43680 APP Homo sapiens P05067
Y2H Pooling
32814053
Intra
TCF21 O43680 APP Homo sapiens P05067
Validated Y2H
32814053
Intra
TCF21 O43680 APP Homo sapiens P05067
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

TCF21 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82356 Transcription Factor 21 Antibody (YA2101) WB, IP, FC Human

Related Diseases

Diseases Alias
Paralytic Ileus

  • Adynamic Ileus

  • Paralytic Ileus Of Bowel

  • Ileus Nos

  • Paralysis Of Bowel

  • Paralysis Of Intestine

  • Adynamic Intestinal Obstruction

  • Paralytic Intestinal Ileus
Pain Agnosia

  • Analgesia
Subacute Lymphocytic Thyroiditis
Pericoronitis

  • Operculitis
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Peroneal Nerve Paralysis

  • Peroneal Nerve Palsy
Mediastinitis
Femoral Cancer

  • Femoral Neoplasms

  • Cancer Of The Femur

  • Femoral Neoplasm

  • Neoplasm Of Femur
Median Arcuate Ligament Syndrome

  • Celiac Artery Compression Syndrome

  • Dunbar Syndrome

  • Mals

  • Harjola-Marable Syndrome

  • Marable'S Syndrome

  • Celiac Axis Syndrome
Spondylolisthesis

  • Slipped Vertebrae

  • Acquired Spondylolisthesis
Intestinal Obstruction

  • Inspissated Milk Syndrome

  • Milk Curd Syndrome
Aspiration Pneumonia

  • Pneumonia, Aspiration

  • Pneumonia Aspiration

  • Aspiration Pneumonitis
Supine Hypotensive Syndrome

  • Maternal Hypotension Syndrome

  • Antepartum Maternal Hypotension Syndrome

  • Postpartum Maternal Hypotension Syndrome

  • Maternal Hypotension Syndrome, Antepartum Condition Or Complication

  • Maternal Hypotension Syndrome, Postpartum Condition Or Complication

  • Maternal Hypotension Syndrome, Unspecified Trimester
Inguinal Hernia

  • Hernia Inguinal

  • Hernia, Inguinal

  • Inguinal Hernias

  • Bubonocele

  • Indirect Inguinal Hernia

  • Direct Inguinal Hernia

  • Oblique Inguinal Hernia

  • Scrotal Hernia

  • Ih - [Inguinal Hernia]
Specific Developmental Disorder
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14303 TCF21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21064 Tcf21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27581 Tcf21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TCF21 MGD MGI:1202715
Canis familiaris TCF21 VGNC VGNC:47193
Macaca mulatta TCF21 VGNC VGNC:78286
Felis catus TCF21 VGNC VGNC:66024
Bos taurus TCF21 VGNC VGNC:35690
Rattus norvegicus TCF21 RGD RGD:620523
Others TCF21 NCBI