CBR4 - carbonyl reductase 4 Gene

Also Known as SDR45C1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84869

About CBR4

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,894,486-169,010,255 (from NCBI)

This gene has 7 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in lung (RPKM 23.4), fat (RPKM 17.8) and 25 other tissues.

Summary

Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex. [provided by Alliance of Genome Resources, Apr 2022]

CBR4 Products (1)

mRNA Protein Name
NM_032783.5 NP_116172.2 3-oxoacyl-[acyl-carrier-protein] reductase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
IDA: Inferred from direct assay
19571038 GOA
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
IMP: Inferred from mutant phenotype
25203508 GOA
enables NAD(P)H dehydrogenase (quinone) activity IDA
IDA: Inferred from direct assay
20837989 GOA
enables NADPH binding IDA
IDA: Inferred from direct assay
19000905 GOA
enables NADPH dehydrogenase (quinone) activity IDA
IDA: Inferred from direct assay
19000905 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19571038 GOA
enables quinone binding IDA
IDA: Inferred from direct assay
19000905 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in daunorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in doxorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
25203508 GOA
involved in protein heterotetramerization IDA
IDA: Inferred from direct assay
25203508 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
19000905 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
19000905 GOA
part of oxidoreductase complex IDA
IDA: Inferred from direct assay
19571038 GOA
part of oxidoreductase complex IMP
IMP: Inferred from mutant phenotype
25203508 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBR4 Protein Structure

adh_short

adh_short: short chain dehydrogenase (3 - 166)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

3-oxoacyl-[acyl-carrier-protein] reductase

  • 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit

CBR4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CBR4 Q8N4T8 ZXDC Homo sapiens Q2QGD7
Y2H Array
32296183
Intra
CBR4 Q8N4T8 ZXDC Homo sapiens Q2QGD7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bile Acid Synthesis Defect, Congenital, 5

  • Congenital Bile Acid Synthesis Defect 5

  • CBAS5

  • Bile Acid Synthesis Defect, Congenital, Type 5
Horner'S Syndrome

  • Horner Syndrome

  • Bernard-Horner Syndrome

  • Oculosympathetic Palsy

  • Bernard Horner Syndrome

  • Cervical Sympathetic Paralysis

  • Von Passow Syndrome

  • Cervical Sympathetic Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02006 CBR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20701 Cbr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27212 Cbr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CBR4 VGNC VGNC:26815
Mus musculus CBR4 MGD MGI:2384567
Macaca mulatta CBR4 VGNC VGNC:70635
Canis familiaris CBR4 VGNC VGNC:38765
Rattus norvegicus CBR4 RGD RGD:727826
Felis catus CBR4 VGNC VGNC:60424
Others CBR4 NCBI