Hedgehog IN-2
Hedgehog IN-2 (Compound 20) is an inhibitor of Hedgehog pathway with an IC50 value less than 0.003 μM in C3H10T1/2 cells.
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- CAS. Nr.: 1126365-74-9
- Formel: C24H22N4O2
- Molecular Weight:398.46
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | EC50 |
0.015 μM
Compound: 11e
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Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis
Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis
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[PMID: 22704236] |
| NIH3T3 | IC50 |
0.0026 μM
Compound: 11e
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Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay
Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay
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[PMID: 22704236] |
In Vitro
Hedgehog IN-2 (3 μM; 72 h) inhibits the Hedgehog pathway with an inhibition rate of 58.1% in C3H10T1/2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:C3H10T1/2 cells
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Concentration:3 μM
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Incubation Time:72 h
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Result:Inhibited the Hedgehog pathway with an inhibition rate of 58.1% in C3H10T1/2 cells.
Chemical Information
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CAS. Nr. 1126365-74-9
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Molecular Weight 398.46
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Formel C24H22N4O2
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SMILES
O=C(C1=CC=C(C=C1)OCC2=NC=CC=C2)NC3=C(C)C=CC(C4=NC(C)=CN4)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Hedgehog IN-2 Related Classifications
HY-153456 Related Classifications
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