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Art. -Nr.: HY-149467

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JMX0254

JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC₅₀ for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2375960-04-4
Formel: C₂₅H₂₅Cl₂N₅O₂
Molecular Weight:498.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

JMX0254 Chemical Structure

CAS. Nr.: 2375960-04-4

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>10 μM Compound: 15; JMX0254	Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay	[PMID: 31403780]

Chemical Information

CAS. Nr. 2375960-04-4
Molecular Weight 498.40
Formel C₂₅H₂₅Cl₂N₅O₂
SMILES

O=C1[C@@]2(C3=C(NC(C2)=O)N(N=N3)[C@H](C4=CC=C(C=C4)Cl)C)C5=CC(Cl)=CC=C5N1CCC(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu J, et al. Design, synthesis, and biological evaluation of substituted 4, 6-dihydrospiro [[1, 2, 3] triazolo [4, 5-b] pyridine-7, 3′-indoline]-2′, 5 (3 H)-dione analogues as potent NS4B inhibitors for the treatment of dengue virus infection[J]. Journal of medicinal chemistry, 2019, 62(17): 7941-7960.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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