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Art. -Nr.: HY-184460

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Nafuredin A

Nafuredin A is a trinorsesquiterpene and polyketide derivative found in the mangrove sediment-derived fungi Talaromyces sp. SCSIO 41412 and Trichoderma harzianum D13. Nafuredin A regulates the ferroptosis pathway and upregulates ferroptosis-related genes. Nafuredin A alleviates hypoxia-reoxygenation-induced injury in oxygen-glucose deprivation/reperfusion cell models. Nafuredin A reduces pro-inflammatory cytokines and exerts hepatoprotective effects in animal models of hepatic ischemia-reperfusion injury. Nafuredin A inhibits the growth of phytopathogenic fungi Magnaporthe oryzae and Valsa mali. Nafuredin A can be used in studies related to hepatic ischemia-reperfusion injury and phytopathogenic fungal infections.

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CAS. Nr.: 224427-79-6
Formel: C₂₂H₃₂O₄
Molecular Weight:360.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nafuredin A Chemical Structure

CAS. Nr.: 224427-79-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Nafuredin A (compound 3) (200-400 µM; 24 h) exhibits extremely low cytotoxicity against HepG2 cells at 200 µM, with an IC₅₀ value of 303.6 µM^[1].
Nafuredin A (200 µM; 24 h) enriches the ferroptosis pathway and upregulates ferroptosis-related genes NRF2, SLC7A11, FTH1, HMOX1, GCLC and GCLM when applied to HepG2 cells^[1].
Nafuredin A (2.5-10 µM; 24 h pre-incubation) significantly reduces OGD/R-induced cytotoxicity in AML12 cells in a concentration-dependent manner^[1].
Nafuredin A (compound 2) inhibits the growth of Magnaporthe oryzae with an MIC of 17.4 μM, inhibits Valsa mali with an MIC of 16.7 μM, and shows no activity against Pestallozzia theae^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human hepatocellular carcinoma HepG2 cells
Concentration:

200, 267, 300, 333, 367, 400 µM
Incubation Time:

24 h
Result:

Showed minimal toxicity to HepG2 cells at 200 µM.

Real Time qPCR^[1]

Cell Line:

human hepatocellular carcinoma HepG2 cells
Concentration:

100 µM
Incubation Time:

24 h
Result:

Robustly upregulated core ferroptosis regulatory genes: NRF2, SLC7A11, FTH1, HMOX1, GCLC, and GCLM.

Cell Viability Assay^[1]

Cell Line:

mouse hepatocyte AML12 cells
Concentration:

2.5, 5, 10 µM
Incubation Time:

24 h (pre-incubation)
Result:

Significantly attenuated OGD/R-induced cytotoxicity in a concentration-dependent manner.
Restored cellular viability.

In Vivo

Nafuredin A (compound 3) (10 mg/kg; i.p.; daily; 3 days) exerts hepatoprotective effects against murine hepatic ischemia-reperfusion injury, reducing serum ALT and AST levels by ≥ 45% and mitigating pro-inflammatory cytokine production and histopathological damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male, 6-8 weeks old, 20-23 g, hepatic ischemia-reperfusion injury model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; daily; 3 days
Result:

Lowered serum ALT and AST levels by no less than 45% versus untreated groups.
Cut serum IL-1β content and hepatic IL-1β/IL-18 mRNA expression prominently.
Alleviated HIRI-triggered liver injury via relieving nuclear pyknosis, recovering sinusoidal endothelial integrity and rearranging hepatic cords.

Chemical Information

CAS. Nr. 224427-79-6
Molecular Weight 360.49
Formel C₂₂H₃₂O₄
SMILES

C[C@@]12[C@@]([C@H](C(O[C@@H]2/C=C/C=C/[C@H](C)C/C(C)=C/C=C/[C@@H](C)CC)=O)O)([H])O1
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Talaromyces aculeatus and amangrove-derived fungus Penicillium variabile
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lan W, et al. Discovery of a Hepatoprotective Trinor-Sesterterpenoid from the Marine Fungus sp. Against Hepatic Ischemia-Reperfusion Injury. Marine drugs. 2025 Aug 16;23(8):329. [Content Brief]

[2]. Zhao D L, et al. Antifungal Nafuredin and Epithiodiketopiperazine Derivatives From the Mangrove-Derived Fungus Trichoderma harzianum D13. Frontiers in Microbiology, 2020, 11: 01495.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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