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Art. -Nr.: HY-174318

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NARS-3′

NARS-3′ is an orally active reversible xanthine oxidase (XO) inhibitor with the IC₅₀ of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia.

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CAS. Nr.: 2702589-46-4
Formel: C₁₅H₁₁NaO₈S
Molecular Weight:374.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NARS-3′ Chemical Structure

CAS. Nr.: 2702589-46-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

NARS-3′ (0-100 μM) exhibits dose-dependent inhibition on XO activity^[1].

NARS-3′ (0-40 μM) can bind to the active site of XO and compete with xanthine substrates during the catalytic process^[1].

NARS-3′ could cause the conformational changes in XO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NARS-3′ (25-100 mg/kg; i.g.; once daily; for a week) can effectively suppress serum XO activity, reduce serum uric acid (UA) levels in the Potassium oxonate (PO) (HY-17511) induced hyperuricemia mice and exhibits significant protective effects on the kidneys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Potassium oxonate (250 mg/kg) injected the male Kunming mice (4 weeks)^[1].
Dosage:

0.3 % carboxymethyl cellulose sodium solution
Administration:

Oral gavage (i.g.); once daily for a week
Result:

Reduced serum UA levels to 56.26 μM and reduced XO activity to 9.21 U/L.
Lowered serum CRE levels to 7.85 μM and reduce pathological damage to the kidneys.

Chemical Information

CAS. Nr. 2702589-46-4
Molecular Weight 374.30
Formel C₁₅H₁₁NaO₈S
SMILES

O=C1CC(OC2=CC(O)=CC(O)=C12)C3=CC(S(=O)(O[Na])=O)=C(C=C3)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Luo Y, et al. Xanthine oxidase inhibitory and anti-hyperuricemic properties of sulfonate derivatives of naringenin. Bioorg Chem. 2025 May 20;163:108618. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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