Natural PTP1B inhibitors from Broussonetia papyrifera

  • Bioorg Med Chem Lett. 2002 Dec 2;12(23):3387-90. doi: 10.1016/s0960-894x(02)00757-6.
Rong Min Chen  1 ,  Li Hong Hu ,  Tian Ying An ,  Jia Li ,  Qiang Shen
Affiliations
  • 1. Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
PMID: 12419367 DOI: 10.1016/s0960-894x(02)00757-6
Abstract

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.

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