Chemical constituents from Inonotus obliquus and their biological activities

  • J Nat Prod. 2014 Jan 24;77(1):35-41. doi: 10.1021/np400552w.
Chao Liu  1 ,  Cui Zhao ,  Hong-Hui Pan ,  Jie Kang ,  Xiong-Tao Yu ,  Hong-Qing Wang ,  Bao-Ming Li ,  Yi-Zhen Xie ,  Ruo-Yun Chen
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 24359303 DOI: 10.1021/np400552w
Abstract

Seven new Triterpenes, inonotusol A-G (1-7), one new diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR ((1)H-(1)H COSY, ROESY, HSQC, and HMBC) experiments. In in vitro assays, compounds 6 and 8-16 showed hepatoprotective effects against d-galactosamine-induced WB-F344 cell damage, with inhibitory effects from 34.4% to 81.2%. Compounds 7, 17, and 18 exhibited selective cytotoxicities against KB, Bel-7402, or A-549 cell lines. Compounds 16 and 17 showed inhibitory effects against Protein Tyrosine Kinases, with IC50 values of 24.6 and 7.7 μM, respectively.

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