In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977)

  • Antimicrob Agents Chemother. 2017 May 24;61(6):e00120-17. doi: 10.1128/AAC.00120-17.
Ryuta Kishii  1 ,  Yuko Yamaguchi  2 ,  Masaya Takei  2
Affiliations
  • 1. Watarase Research Center, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan [email protected].
  • 2. Watarase Research Center, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
PMID: 28320717 DOI: 10.1128/AAC.00120-17
Abstract

Lascufloxacin exhibited a broad spectrum of activity against various clinical isolates. Furthermore, lascufloxacin showed the most potent activity against Gram-positive bacteria among the quinolones tested and incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin had potent inhibitory activity against both wild-type and mutated target Enzymes. These results suggest that lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains.

Keywords
antimicrobial activity; antimicrobial agents; quinolones.
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