Spermine-15N2
Spermine-15N2 (NSC 268508-15N2) is the 15N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro.
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- CAS. Nr.: 93827-50-0
- Formel: C10H26N215N2
- Molecular Weight:204.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 93827-50-0
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Molecular Weight 204.33
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Formel C10H26N215N2
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SMILES
NCCC[15NH]CCCC[15NH]CCCN
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Synonyms
NSC 268508-15N2; Neuridine-15N2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. Dawson, M., & Dryden, W. F. (1969). The toxicity of spermine and spermidine to cells in culture. Biochemical pharmacology, 18(6), 1307-1313. [Content Brief]
[3]. Byrd, W. J., et al., (1977). Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature, 267(5612), 621–623. [Content Brief]
[4]. Løvaas, E., & Carlin, G. (1991). Spermine: an anti-oxidant and anti-inflammatory agent. Free radical biology & medicine, 11(5), 455-461. [Content Brief]
[6]. Otsuki, M., et al., (1995). In vivo pharmacological study of spermine-induced neurotoxicity. Neuroscience letters, 196(1-2), 81-84. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Spermine-15N2 Related Classifications
HY-B1777S Related Classifications
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