Xanthofulvin
Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury.
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- CAS. Nr.: 151466-15-8
- Formel: C28H18O14
- Molecular Weight:578.43
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Speicherung:
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Xanthofulvin (0-1 μg/mL; 2 h) potently inhibits Semaphorin3A (Sema3A)-induced growth cone collapse of E7 chicken dorsal root ganglion neurons cultured in vitro, with an IC50 of 0.09 μg/mL, and does not alter the morphology of DRG cells in the absence of Sema3A[1].
Xanthofulvin (0.16-2 μM; 0-2 h) potently inhibits Sema3A-induced growth cone collapse in E7 chicken dorsal root ganglion (DRG) explants, with an IC50 of 0.16 μM, and completely blocks the collapse at concentrations below 2 μM[2].
Xanthofulvin (0-4.0 μM; 0-2 days) dose-dependently blocks Sema3A-induced axonal repulsion in E8 chicken dorsal root ganglion (DRG) explants co-cultured with Sema3A-expressing COS7 cells[2].
Xanthofulvin (5-500 μM; 48 h) exhibits no cytotoxicity against COS7 cells even at concentrations up to 500 μM with a 48 h incubation[2].
Xanthofulvin inhibits the binding of Sema3A-AP to NP-1-expressing COS7 cells in a dose-dependent manner, with an IC50 of 2.9 μM, and significantly reduces the binding at 5 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COS7 cells
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Concentration:5 μM; 50 μM; 500 μM
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Incubation Time:48 h
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Result:Showed no growth inhibition of COS7 cells at concentrations up to 500 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 6.5 weeks old, olfactory nerve axotomy model)[2]
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Dosage:6 μg/6 μl/day
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Administration:local continuous via cannula and osmotic pump at the injury site
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Result:Achieved a mean olfactory nerve regeneration score of 8.3 at 2 weeks post-axotomy.
Achieved a mean olfactory nerve regeneration score of 5.2 at 3 weeks post-axotomy, which was significantly lower than the vehicle control group.
Chemical Information
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CAS. Nr. 151466-15-8
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Molecular Weight 578.43
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Formel C28H18O14
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SMILES
O=C(C(C(O)=C(C=C1OC2=C3C=C(C(C)=C2C(C)=O)/C(O)=C4C(C5=C(C(O)=O)C(O)=C(O)C=C5OC/4)=O)O)=C1C3=O)O
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Synonyms
SM-216289
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kumagai K, et al. Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium. J Antibiot (Tokyo). 2003 Jul;56(7):610-6. [Content Brief]
[2]. Kikuchi K, et al. In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J Biol Chem. 2003;278(44):42985-42991. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Xanthofulvin Related Classifications
HY-N14827 Related Classifications
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