country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-189902

Copy Link Print Information

YH-685

YH-685 is a cytochrome bd oxidase (Cyt-bd) inhibitor. YH-685 enhances the inhibitory effect of Cyt-bcc inhibitors on planktonic and intracellular Mycobacterium tuberculosis by targeting the terminal oxidase of the mycobacterial electron transport chain. YH-685 can be used for research on tuberculosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3037358-52-1
Formel: C₁₈H₁₂F₅NO₃
Molecular Weight:385.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

YH-685 Chemical Structure

CAS. Nr.: 3037358-52-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	61.7 μM	Cytotoxicity against human HepG2 cells. Cytotoxicity against human HepG2 cells.	acsmedchemlett.6c00310

In Vitro

Anti-cancerBacterial InfectionInnate ImmunityOthers

Anti-cancer

YH-685 exhibits cytotoxicity against HepG2 cells with an IC₅₀ value of 61.7 μM^[1].

Bacterial Infection

YH-685 (compound 17aa) (0.8 μM) inhibits the growth of the Cyt-bcc-deficient Mycobacterium smegmatis ΔqcrCAB, with an MIC of 0.8 μM^[1].

Bacterial Infection

Innate Immunity

YH-685 (100 μM) enhances the inhibitory effect of TB47 on planktonic and intracellular Mtb H37Rv, producing an additional 29.7% inhibition in planktonic culture and an additional 14.5% inhibition in human macrophages compared with TB47 alone^[1].

Others

YH-685 (10 μM) inhibits Cyt-bd-dependent oxygen consumption in Mycobacterium smegmatis Δbcc inverted membrane vesicles, with an IC₅₀ of 0.45 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3037358-52-1
Molecular Weight 385.28
Formel C₁₈H₁₂F₅NO₃
SMILES

O=C1C(CC2=CC=C(OC(F)(F)F)C=C2)=C(C)N(O)C3=C1C=C(F)C(F)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Qiao Qin, et al. Design, Synthesis, and Antimicrobial Activity of Novel Cyt-bd Inhibitors Targeting Energy Compensation in Mycobacterium tuberculosis. ACS Med. Chem. Lett. 8 October 2026; 17 (10): 2182–2190.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen