Alas1 - aminolevulinic acid synthase 1 Gene

Also Known as ALAS; ALAS-N; Alas-1; Alas-h

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11655

Summary

Predicted to enable 5-aminolevulinate synthase activity and identical protein binding activity. Predicted to be involved in erythrocyte development; heme biosynthetic process; and Hemoglobin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; liver; and male reproductive system. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Alas1 Products (2)

mRNA Protein Name
NM_001291835.1 NP_001278764.1 5-aminolevulinate synthase, non-specific, mitochondrial precursor
NM_020559.2 NP_065584.2 5-aminolevulinate synthase, non-specific, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5-aminolevulinate synthase activity IMP
IMP: Inferred from mutant phenotype
24821812 MGI
Biological Process GO Annotation Evidence References Source
involved in heme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
33307066 MGI
involved in heme B biosynthetic process IMP
IMP: Inferred from mutant phenotype
33307066 MGI
involved in heme O biosynthetic process IMP
IMP: Inferred from mutant phenotype
33307066 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
34900592 MGI
is active in mitochondrial matrix IMP
IMP: Inferred from mutant phenotype
33307066 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-aminolevulinate synthase, non-specific, mitochondrial

  • 5-aminolevulinate synthase, nonspecific, mitochondrial

  • 5-aminolevulinic acid synthase 1

  • aminolevulinate synthase H

  • delta-ALA synthase 1

  • delta-aminolevulinate synthase 1

  • succinyl-CoA: glycine C-succinyl transferase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132610A Givosiran sodium 98.71% Unkown
HY-132610 Givosiran 96.95% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00554 ALAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17599 Alas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24059 Alas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alas1 NCBI NCBI:211