NRBP1 - nuclear receptor binding protein 1 Gene

Also Known as MADM; NRBP; BCON3; MUDPNP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29959

About NRBP1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,427,790-27,442,259 (from NCBI)

This gene has 9 transcripts (splice variants), 272 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues.

Summary

Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]

NRBP1 Products (7)

mRNA Protein Name
NM_001321357.2 NP_001308286.1 nuclear receptor-binding protein isoform 1
NM_001321358.2 NP_001308287.1 nuclear receptor-binding protein isoform 2
NM_001321359.2 NP_001308288.1 nuclear receptor-binding protein isoform 2
NM_001321361.2 NP_001308290.1 nuclear receptor-binding protein isoform 3
NM_001321362.2 NP_001308291.1 nuclear receptor-binding protein isoform 4
NM_001321363.2 NP_001308292.1 nuclear receptor-binding protein isoform 5
NM_013392.4 NP_037524.1 nuclear receptor-binding protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11956649 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
11956649 GOA
Cellular Component GO Annotation Evidence References Source
located in endomembrane system IDA
IDA: Inferred from direct assay
11956649 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRBP1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (83 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

nuclear receptor-binding protein

  • multiple domain putative nuclear protein

NRBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q8IV54
Y2H Prey Pooling
25416956
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q8IV54
Validated Y2H
25416956
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q8IV54
Y2H Array
25416956
Intra
NRBP1 Q9UHY1 C2orf50 Homo sapiens Q96LR7
Y2H Prey Pooling
32296183
Intra
NRBP1 Q9UHY1 C2orf50 Homo sapiens Q96LR7
Y2H Array
32296183
Intra
NRBP1 Q9UHY1 SNX31 Homo sapiens Q8N9S9-2
Y2H Array
32296183
Intra
NRBP1 Q9UHY1 SNX31 Homo sapiens Q8N9S9-2
Y2H Prey Pooling
32296183
Cross
NRBP1 Q9UHY1 Sall4 Mus musculus Q8BX22
Anti Tag CoIP
22510880
Cross
NRBP1 Q9UHY1 Sall4 Mus musculus Q8BX22
TAP
22510880
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Pooling
16189514
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q9Y3Q8
MAPPIT
25416956
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q9Y3Q8
Pull Down
32707033
Intra
NRBP1 Q9UHY1 TSC22D4 Homo sapiens Q9Y3Q8
Anti Tag CoIP
35271311
Intra
NRBP1 Q9UHY1 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
NRBP1 Q9UHY1 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
NRBP1 Q9UHY1 RAC3 Homo sapiens P60763
IF
11956649
Intra
NRBP1 Q9UHY1 RAC3 Homo sapiens P60763
Y2H
11956649
Cross
NRBP1 Q9UHY1 polg_den2n Dengue virus type 2 P14340
Anti Tag CoIP
15084397
Cross
NRBP1 Q9UHY1 polg_den2n Dengue virus type 2 P14340
Y2H
15084397
Cross
NRBP1 Q9UHY1 polg_den2n Dengue virus type 2 P14340
Imaging
15084397
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09562 NRBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NRBP1 MGD MGI:2183436
Bos taurus NRBP1 VGNC VGNC:32255
Canis familiaris NRBP1 VGNC VGNC:43961
Rattus norvegicus NRBP1 RGD RGD:1589575
Felis catus NRBP1 VGNC VGNC:68561
Macaca mulatta NRBP1 VGNC VGNC:75524
Others NRBP1 NCBI