AKNA - AT-hook transcription factor Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80709

About AKNA

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,330,504-114,398,472 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues and 1 paralogue. Broad expression in spleen (RPKM 28.7), lymph node (RPKM 23.1) and 20 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

AKNA Products (3)

mRNA	Protein	Name
NM_001317950.2	NP_001304879.1	microtubule organization protein AKNA isoform 1
NM_001317952.1	NP_001304881.1	microtubule organization protein AKNA isoform 2
NM_030767.5	NP_110394.3	microtubule organization protein AKNA isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16000308	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11268217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKNA Protein Structure

AKNA

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300
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1439 a.a.

Protein Preferred Names	Protein Names
microtubule organization protein AKNA	AKNA transcript F2

AKNA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKNA	Q7Z591	CD2BP2	Homo sapiens	O95400	NMR	16000308

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vogt-Koyanagi-Harada Disease	Uveomeningoencephalitic Syndrome Uveomenigitic Syndrome Vogt-Koyanagi-Harada Syndrome Harada'S Disease Vogt-Koyanagi Syndrome Vkh Disease Vkh Syndrome Vkh
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00529	AKNA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22101	Akna Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28621	Akna Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKNA	RGD	RGD:1308202
Mus musculus	AKNA	MGD	MGI:2140340
Bos taurus	AKNA	VGNC	VGNC:55031
Macaca mulatta	AKNA	VGNC	VGNC:69684
Canis familiaris	AKNA	VGNC	VGNC:37767
Felis catus	AKNA	VGNC	VGNC:59722
Others	AKNA	NCBI