Sh3gl1 - SH3 domain containing GRB2 like 1, endophilin A2 Gene

Also Known as SH3P8

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81922

Summary

Enables several functions, including SH3 domain binding activity; beta-1 Adrenergic Receptor binding activity; and enzyme binding activity. Involved in modulation of excitatory postsynaptic potential and positive regulation of synaptic vesicle endocytosis. Located in membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Used to study high grade glioma. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl1 Products (1)

mRNA	Protein	Name
NM_031239.3	NP_112518.1	endophilin-A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	9238017	RGD
enables SH3 domain binding	IMP IMP: Inferred from mutant phenotype	22750032	RGD
enables beta-1 adrenergic receptor binding	IMP IMP: Inferred from mutant phenotype	22750032	RGD
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9238017	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11498538	RGD
enables transmembrane transporter binding	IMP IMP: Inferred from mutant phenotype	22750032	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22961472	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	22750032	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	14532001	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	22750032	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11518713	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17088211	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	11518713	RGD
located in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	11518713	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	17088211	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	17088211	RGD
is active in synapse	IDA IDA: Inferred from direct assay	11518713	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endophilin-A2	SH3 domain protein 2B SH3 domain-containing GRB2-like 1 SH3 domain-containing GRB2-like protein 1 SH3-domain GRB2-like 1 endophilin-2

Sh3gl1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Sh3gl1	O35964	RAPH1	Homo sapiens	Q70E73	Far-WB	24076656
Cross	Sh3gl1	O35964	RAPH1	Homo sapiens	Q70E73	Peptide Array	24076656
Cross	Sh3gl1	O35964	RAPH1	Homo sapiens	Q70E73	Pull Down	24076656
Cross	Sh3gl1	O35964	RAPH1	Homo sapiens	Q70E73	IF	24076656

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12836	SH3GL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3gl1	NCBI	NCBI:6455