AB10
AB10 is a selective S1R antagonist. AB10 with Ki of 10, 165 nM for S1R and S2R, respectively. AB10 reverses the effect of Capsaicin (HY-10448) caused pain in model.
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- Formule: C23H30N2
- Masse moléculaire:334.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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Sigma 1 Receptor 10 nM (Ki) |
Sigma 2 Receptor 165 nM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Capsaicin-induced as a pain model in CD1 mice[1]
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Dosage:20 mg/kg
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Administration:subcutaneous injection performed in different areas of the interscapular zone, administered 30 min before the injection of Capsaicin (HY-10448).
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Result:Achieved similar effects at half the concentration of BD-1063 (HY-18101A) (40mg/kg). Showed complete reversal of the mechanical hypersensitivity reaction.
Chemical Information
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Masse moléculaire 334.50
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Formule C23H30N2
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SMILES
C1(CN(CC2=CC=CC=C2)C3)C3CCCN1CCCC4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB10 Related Classifications
HY-149855 Related Classifications
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