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Cat. No.: HY-W674149

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ABI-274

ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib (HY-12057). ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma.

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CAS No.: 1253697-93-6
Formule: C₂₀H₂₀N₂O₄
Masse moléculaire:352.38

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ABI-274 Chemical Structure

CAS No.: 1253697-93-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	18.7 nM Compound: ABI-274	Antiproliferative activity against human A375 cells measured after 72 hrs by MTS assay Antiproliferative activity against human A375 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
A-375	IC₅₀	9 nM Compound: 5da	Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
A-375	IC₅₀	9 nM Compound: 5da3	Cytotoxicity against human A375 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A375 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23547728]
B16-F1	IC₅₀	46 nM Compound: 5da	Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
DU-145	IC₅₀	11 nM Compound: 5da3	Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23547728]
DU-145	IC₅₀	15 nM Compound: 5da	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
LNCaP	IC₅₀	12 nM Compound: 5da	Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
LNCaP	IC₅₀	12 nM Compound: 5da3	Cytotoxicity against human LNCAP cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human LNCAP cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23547728]
M14	IC₅₀	6.9 nM Compound: ABI-274	Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
MDA-MB-231	IC₅₀	25.3 nM Compound: ABI-274	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
MDA-MB-435	IC₅₀	5 nM Compound: 5da3	Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23547728]
MDA-MB-453	IC₅₀	11.4 nM Compound: ABI-274	Antiproliferative activity against human MDA-MB-453 cells measured after 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-453 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
PC-3	IC₅₀	9 nM Compound: 5da	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PC-3	IC₅₀	9 nM Compound: 5da3	Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23547728]
PPC-1	IC₅₀	11 nM Compound: 5da	Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PPC-1	IC₅₀	15 nM Compound: 5da3	Cytotoxicity against human PPC1 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human PPC1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23547728]
RPMI-7951	IC₅₀	6.4 nM Compound: ABI-274	Antiproliferative activity against human RPMI7951 cells measured after 72 hrs by MTS assay Antiproliferative activity against human RPMI7951 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
SK-BR-3	IC₅₀	12.5 nM Compound: ABI-274	Antiproliferative activity against human SK-BR-3 cells measured after 72 hrs by MTS assay Antiproliferative activity against human SK-BR-3 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
WM164	IC₅₀	8 nM Compound: 5da	Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]

Chemical Information

CAS No. 1253697-93-6
Masse moléculaire 352.38
Formule C₂₀H₂₀N₂O₄
SMILES

COC1=CC(C(C2=CN=C(C3=CC=C(C=C3)C)N2)=O)=CC(OC)=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang, J., et al., (2014). Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Molecular cancer therapeutics, 13(1), 16–26. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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