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Cat. No.: HY-149805

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Anticancer agent 110

Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis.

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CAS No.: 887349-03-3
Formule: C₁₈H₁₃FN₆OS
Masse moléculaire:380.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 110 Chemical Structure

CAS No.: 887349-03-3

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	IC₅₀	772 nM Compound: 3d	Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
HaCaT	IC₅₀	>100 μM Compound: 3d	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
HCT-15	IC₅₀	347 nM Compound: 3d	Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
J774.2	IC₅₀	70.67 μM Compound: 3d	Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
K562	IC₅₀	0.7 μM Compound: 3d	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
K562	IC₅₀	56.4 nM Compound: 3d	Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
KM12	IC₅₀	927 nM Compound: 3d	Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
LOX IMVI	IC₅₀	206 nM Compound: 3d	Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
M14	IC₅₀	261 nM Compound: 3d	Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
NCI-H460	IC₅₀	993 nM Compound: 3d	Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
NIH3T3	IC₅₀	>100 μM Compound: 3d	Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
SW-620	IC₅₀	118 nM Compound: 3d	Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
T47D	IC₅₀	896 nM Compound: 3d	Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
UACC-62	IC₅₀	56.9 nM Compound: 3d	Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]

In Vitro

Anticancer agent 110 (compound 3d) (0.01 μM-100 μM) inhibits leukemia K-562 cells with IC₅₀ of 0.7 μM^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) causes a higher level of DNA damage in K-562 cells^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) induces pro-apoptotic changes in the morphology of leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 887349-03-3
Masse moléculaire 380.40
Formule C₁₈H₁₃FN₆OS
SMILES

O=C(C1=CC=C(N2N=NN=C2)C=C1)NC3=NC=C(CC4=CC=C(C=C4)F)S3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pokhodylo N, et al. Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides. Eur J Med Chem. 2023 Mar 15;250:115126. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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