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Cat. No.: HY-171956

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Carmaphycin-17

Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC₅₀ of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research.

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CAS No.: 2143080-91-3
Formule: C₄₀H₄₅N₅O₅
Masse moléculaire:675.82

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Carmaphycin-17 Chemical Structure

CAS No.: 2143080-91-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
Chemical Information
Pureté et documentation
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	346 nM Compound: 17	Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay	[PMID: 28696697]

Chemical Information

CAS No. 2143080-91-3
Masse moléculaire 675.82
Formule C₄₀H₄₅N₅O₅
SMILES

O=C([C@]1(CO1)C)[C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CCCCC)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CNC6=CC=CC=C56)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. O'Donoghue AJ, et al. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00448-19. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Carmaphycin-17

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Carmaphycin-17 Related Classifications

HY-171956 Related Classifications