442633-00-3
442633-00-3
Chemical Structure
CK-666
- CAS No.: 442633-00-3
- Formula:C18H17FN2O
- Molecular Weight:296.34
IUPAC Name: 2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
InChIKey: UXRKUKRXVWJFER-UHFFFAOYSA-N
SMILES: O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F
Biological Activity: CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].
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CK-666 | 99.95% | CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. | ||||||||||||||||||||
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CK-666 (Standard) | ≥98% | CK-666 (Standard) is the analytical standard of CK-666 (HY-16926). This product is intended for research and analytical applications. CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocKing movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. | ||||||||||||||||||||
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References
- [1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12. [Content Brief]
- [2]. Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4+ T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70. [Content Brief]
