CK-666 (Standard)
CK-666 (Standard) is the analytical standard of CK-666 (HY-16926). This product is intended for research and analytical applications. CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocKing movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
For research use only. We do not sell to patients.
- CAS No.: 442633-00-3
- Formula: C18H17FN2O
- Molecular Weight:296.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 442633-00-3
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Molecular Weight 296.34
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Formula C18H17FN2O
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SMILES
O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12. [Content Brief]
[2]. Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4+ T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)