Desaspidin
Desaspidin is an oxidative phosphorylation inhibitor and photophosphorylation inhibitor. Desaspidin uncouples mitochondrial oxidative phosphorylation, multiple chloroplast photophosphorylation pathways, and ATP synthesis linked to non-cyclic NADP reduction. Desaspidin can be used for the research of anthelmintic agent.
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- CAS No.: 114-43-2
- Formule: C24H30O8
- Masse moléculaire:446.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Desaspidin (0.5-2.0 μM; 2 min) uncouples photophosphorylation in isolated spinach chloroplasts, with an IC50 of ~0.5 μM for XE accumulation, reducing XE half-life and ATP yield in a concentration-dependent manner[1].
Desaspidin (1.1 μM; 0.25-20 min) inhibits FMN-catalysed photophosphorylation in isolated spinach chloroplasts completely at short illumination times[1].
Desaspidin (0.1-5 μM) uncouples ferredoxin-catalysed cyclic photophosphorylation in isolated spinach chloroplasts with an IC50 of ~0.2 μM[1].
Desaspidin (100 nM-10 μM) acts as a potent, redox-dependent uncoupler of photophosphorylation in swiss chard, spinach, or lettuce chloroplasts[2].
Desaspidin (5 μM) initially uncouples FMN-driven photophosphorylation in swiss chard, spinach, or lettuce chloroplasts, but its inhibitory activity is lost over time due to photodestruction, with resistance reduced at lower chlorophyll concentrations[2].
Desaspidin (0.5 μM; 10 minutes) strongly inhibits both cyclic and noncyclic (reduced dichlorophenol indophenol-to-TPN) photophosphorylation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 114-43-2
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Masse moléculaire 446.49
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Formule C24H30O8
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SMILES
O=C1C(C(CCC)=O)=C(C(C)(C)C(O)=C1CC2=C(C(C(CCC)=O)=C(C=C2OC)O)O)O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hind G. Effect of desaspidin on photosynthetic phosphorylation and related processes. Nature. 1966 May 14;210(5037):703-8. [Content Brief]
[2]. Gromet-Elhanan Z, et al. Desaspidin: a nonspecific uncoupler of photophosphorylation. Plant Physiol. 1966 Sep;41(7):1231-6. [Content Brief]
[3]. Gromet-Elhanan Z, et al. Effect of desaspidin on photosynthetic phosphorylation. Plant Physiol. 1965 Nov;40(6):1060-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desaspidin Related Classifications
HY-183972 Related Classifications
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