Gpr139 - G protein-coupled receptor 139 Gene

Also Known as PGR3; GPRg1; Gm495

Species: Mus musculus

Gene Type: protein coding
Gene ID: 209776

About Gpr139

Chromosome 7: 118,739,970-118,783,826 reverse strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 335 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in whole brain E14.5 (RPKM 4.1), CNS E18 (RPKM 3.7) and 5 other tissues.

Summary

Enables identical protein binding activity and neuropeptide receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human GPR139 (G protein-coupled receptor 139). [provided by Alliance of Genome Resources, Apr 2022]

Gpr139 Products (1)

mRNA Protein Name
NM_001024138.2 NP_001019309.1 probable G-protein coupled receptor 139

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
16378626 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
16378626 MGI
enables neuropeptide receptor activity IDA
IDA: Inferred from direct assay
16378626 MGI
Biological Process GO Annotation Evidence Références Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
16378626 MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
16378626 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr139 Protein Structure

7tmA_GPR139

7tmA_GPR139: cd15919 (18 - 287)

7tmA_GPR139

7tmA_GPR139: cd15919 (19 - 45)

7tmA_GPR139

7tmA_GPR139: cd15919 (53 - 78)

7tmA_GPR139

7tmA_GPR139: cd15919 (92 - 122)

7tmA_GPR139

7tmA_GPR139: cd15919 (134 - 154)

7tmA_GPR139

7tmA_GPR139: cd15919 (171 - 196)

7tmA_GPR139

7tmA_GPR139: cd15919 (212 - 244)

7tmA_GPR139

7tmA_GPR139: cd15919 (255 - 280)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 139

  • G protein-coupled receptor PGR3

  • g(q)-coupled orphan receptor GPRg1

  • orphan G protein-coupled receptor TRHRL2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-132228 Zelatriazin Agonist 99.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-19838 JNJ-63533054 Agonist 99.80% Unkown
HY-128057 NCRW0005-F05 Antagonist 99.94% Unkown
HY-119168 LP-471756 Antagonist 99.53% Unkown
HY-101777 TC-O 9311 Agonist 99.83% Unkown
HY-149651 GPR139 agonist-2 Agonist 99.85% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr139 NCBI NCBI:124274