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FLII - FLII actin remodeling protein Gene

Also Known as FLI; FLIL; Fli1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2314

About FLII

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,244,815-18,259,022 (from NCBI)

This gene has 30 transcripts (splice variants), 1 gene allele, 203 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 32.8), spleen (RPKM 32.4) and 25 other tissues.

Summary

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

FLII Products (3)

mRNA	Protein	Name
NM_001256264.2	NP_001243193.1	protein flightless-1 homolog isoform 2
NM_001256265.2	NP_001243194.1	protein flightless-1 homolog isoform 3
NM_002018.4	NP_002009.1	protein flightless-1 homolog isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables actin binding	IDA IDA: Inferred from direct assay	9525888	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9671805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLII Protein Structure

LRR_1

LRR_8

LRR_4

Gelsolin

0
200
400
600
800
1000
1200
1269 a.a.

Protein Preferred Names	Protein Names
protein flightless-1 homolog	flightless I actin binding protein

FLII Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	FLII	Q13045	LRRFIP2	Homo sapiens	Q9Y608	Anti Tag CoIP	33961781
Intra	FLII	Q13045	LRRFIP1	Homo sapiens	Q32MZ4	Anti Tag CoIP	33961781
Intra	FLII	Q13045	LRRFIP1	Homo sapiens	Q32MZ4	Y2H	10366446

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Askin'S Tumor	Askin Tumor Askin Tumour Askin'S Tumour
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Ewing Sarcoma Of Bone	Ewing'S Sarcoma Of Bone Bone Ewing Sarcoma Bone Ewing'S Sarcoma Bone Localized Ewing Sarcoma Bone Localized Ewing'S Sarcoma Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor Localized Skeletal Ewing'S Sarcoma Localized Bone Ewing Sarcoma
Skin Angiosarcoma	Angiosarcoma Of Skin Hemangiosarcoma Of The Skin Haemangiosarcoma Of Skin Lymphangiosarcoma Of Skin Cutaneous Angiosarcoma Malignant Haemangioendothelioma Of Skin
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04978	FLII Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FLII	RGD	RGD:1307590
Macaca mulatta	FLII	VGNC	VGNC:72670
Canis familiaris	FLII	VGNC	VGNC:40899
Bos taurus	FLII	VGNC	VGNC:29032
Felis catus	FLII	VGNC	VGNC:62290
Mus musculus	FLII	MGD	MGI:1342286
Others	FLII	NCBI