LRRFIP2 - LRR binding FLII interacting protein 2 Gene

Also Known as HUFI-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9209

About LRRFIP2

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,052,626-37,176,360 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues.

Summary

The protein encoded by this gene, along with MyD88, binds to the cytosolic tail of Toll-like Receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the Caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

LRRFIP2 Products (19)

mRNA Protein Name
NM_001134369.2 NP_001127841.1 leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001282691.1 NP_001269620.1 leucine-rich repeat flightless-interacting protein 2 isoform d
NM_001348297.1 NP_001335226.1 leucine-rich repeat flightless-interacting protein 2 isoform b
NM_001348298.1 NP_001335227.1 leucine-rich repeat flightless-interacting protein 2 isoform c
NM_001348299.1 NP_001335228.1 leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348300.1 NP_001335229.1 leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348301.1 NP_001335230.1 leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348302.1 NP_001335231.1 leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348303.1 NP_001335232.1 leucine-rich repeat flightless-interacting protein 2 isoform g
NM_001348304.1 NP_001335233.1 leucine-rich repeat flightless-interacting protein 2 isoform h
NM_001348305.1 NP_001335234.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348306.1 NP_001335235.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348307.1 NP_001335236.1 leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348308.1 NP_001335237.1 leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348309.1 NP_001335238.1 leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348310.1 NP_001335239.1 leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001348311.1 NP_001335240.1 leucine-rich repeat flightless-interacting protein 2 isoform l
NM_006309.4 NP_006300.1 leucine-rich repeat flightless-interacting protein 2 isoform a
NM_017724.2 NP_060194.1 leucine-rich repeat flightless-interacting protein 2 isoform l

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables LRR domain binding IPI
IPI: Inferred from physical interaction
10366446 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10366446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRFIP2 Protein Structure

LRRFIP

LRRFIP: LRRFIP family (31 - 112)

LRRFIP

LRRFIP: LRRFIP family (292 - 459)

LRRFIP

LRRFIP: LRRFIP family (458 - 646)

  • 0
  • 200
  • 400
  • 600
  • 721 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat flightless-interacting protein 2

  • LRR FLII-interacting protein 2

LRRFIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
31515488
Intra
LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
25416956
Intra
LRRFIP2 Q9Y608 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
Intra
LRRFIP2 Q9Y608 FLII Homo sapiens Q13045
Y2H
10366446
Intra
LRRFIP2 Q9Y608 DVL3 Homo sapiens Q92997
Anti Tag CoIP
15677333
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07831 LRRFIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LRRFIP2 VGNC VGNC:31035
Rattus norvegicus LRRFIP2 RGD RGD:1306234
Canis familiaris LRRFIP2 VGNC VGNC:42820
Macaca mulatta LRRFIP2 VGNC VGNC:74449
Mus musculus LRRFIP2 MGD MGI:1918518
Felis catus LRRFIP2 VGNC VGNC:68094
Others LRRFIP2 NCBI