FLT3LG - fms related receptor tyrosine kinase 3 ligand Gene

Also Known as FL; FLG3L; FLT3L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2323

About FLT3LG

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,474,215-49,486,231 (from NCBI)

This gene has 12 transcripts (splice variants) and 87 orthologues. Ubiquitous expression in spleen (RPKM 4.5), lymph node (RPKM 4.2) and 24 other tissues.

Summary

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

FLT3LG Products (5)

mRNA	Protein	Name
NM_001204502.2	NP_001191431.1	fms-related tyrosine kinase 3 ligand isoform 1 precursor
NM_001204503.2	NP_001191432.1	fms-related tyrosine kinase 3 ligand isoform 1 precursor
NM_001278637.2	NP_001265566.1	fms-related tyrosine kinase 3 ligand isoform 2
NM_001278638.2	NP_001265567.1	fms-related tyrosine kinase 3 ligand isoform 2
NM_001459.4	NP_001450.2	fms-related tyrosine kinase 3 ligand isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in embryonic hemopoiesis	IDA IDA: Inferred from direct assay	21149635	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8180375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLT3LG Protein Structure

Flt3_lig

0
100
200
235 a.a.

Protein Preferred Names	Protein Names
fms-related tyrosine kinase 3 ligand	flt3 ligand

FLT3LG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	FLT3LG	P49771	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	FLT3LG	P49771	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FLT3LG Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7111	FLT3LG Protein, Human (CHO)	P49771-1 (T27-P185)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70544	FLT3LG Protein, Human (HEK293, His)	P49771-1 (T27-P184)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73066	FLT3LG Protein, Human (sf9, His)	P49771-1 (T27-P185)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70544G	GMP FLT3LG Protein, Human (HEK293, His)	P49771-1 (T27-P184)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700072AF	Animal-Free FLT3LG Protein, Human (His)	P49771-1 (T27-A181)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Epiphyseal Dysplasia, Multiple, 3	EDM3 Multiple Epiphyseal Dysplasia 3 Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy Epiphyseal Dysplasia Multiple 3 Dysplasia, Epiphyseal, Multiple, Type 3
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Duodenum Adenoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Dendritic Cell Deficiency
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04993	FLT3LG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23578	Flt3lg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991114	Adezkibart	Ligand	96%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FLT3LG	VGNC	VGNC:40909
Macaca mulatta	FLT3LG	VGNC	VGNC:72680
Felis catus	FLT3LG	VGNC	VGNC:62300
Bos taurus	FLT3LG	VGNC	VGNC:29043
Rattus norvegicus	FLT3LG	RGD	RGD:2322792
Mus musculus	FLT3LG	MGD	MGI:95560
Others	FLT3LG	NCBI