CA12 - carbonic anhydrase 12 Gene

Also Known as CAXII; CA-XII; T18816; HsT18816

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 771

About CA12

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:63,321,378-63,381,846 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues, 14 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 105.5), skin (RPKM 54.4) and 6 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

CA12 Products (4)

mRNA Protein Name
NM_206925.3 NP_996808.1 carbonic anhydrase 12 isoform 2 precursor
NM_001218.5 NP_001209.1 carbonic anhydrase 12 isoform 1 precursor
NM_001293642.2 NP_001280571.1 carbonic anhydrase 12 isoform 3 precursor
NR_135511.2

CA12 Protein Structure

Carb_anhydrase

Carb_anhydrase: Eukaryotic-type carbonic anhydrase (32 - 289)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 12

  • carbonate dehydratase XII

  • carbonic anhydrase XII

  • carbonic dehydratase

  • tumor antigen HOM-RCC-3.1.3

Recombinant CA12 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71720 CA12/Carbonic Anhydrase 12 Protein, Human (P.pastoris, His) O43570 (A25-S301) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72866 CA12/Carbonic Anhydrase 12 Protein, Human (HEK293, His) O43570 (A25-Q291) ≥ 95%, as determined by reducing SDS-PAGE.

CA12 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86796 CA12 Antibody (YA6489) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Lung Leiomyoma

  • Pulmonary Leiomyoma

  • Leiomyoma Of Lung
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Pseudohypoaldosteronism, Type I, Autosomal Recessive

  • Autosomal Recessive Pseudohypoaldosteronism Type 1

  • PHA1B

  • Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism, Type I

  • Generalized Pha1

  • Generalized Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism Type 1 Autosomal Recessive

  • Pha1

  • Pseudohypoaldosteronism

  • Pha I, Autosomal Recessive

  • Autosomal Recessive Pha 1

  • Pseudohypoaldosteronism Type 1, Recessive

  • Pseudohypoaldosteronism Type I

  • Autosomal Recessive Pha1

  • Pha Type 1

  • Pseudohypoaldosteronism 1, Autosomal Recessive

  • Multisystem Pseudohypoaldosteronism

  • Pha Type I, Autosomal Recessive

  • Pseudohypoaldosteronism Type I, Autosomal Recessive
Osteopetrosis, Autosomal Recessive 3

  • Osteopetrosis With Renal Tubular Acidosis

  • Marble Brain Disease

  • OPTB3

  • Guibaud-Vainsel Syndrome

  • Carbonic Anhydrase Ii Deficiency

  • Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis

  • Autosomal Recessive Osteopetrosis 3

  • Carbonic Anhydrase 2 Deficiency

  • Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis

  • Osteopetrosis Autosomal Recessive 3

  • Autosomal Recessive Osteopetrosis Type 3

  • Guibaud Vainsel Syndrome

  • Mixed Rta

  • Mixed Renal Tubular Acidosis

  • Renal Tubular Acidosis Type 3

  • Carbonic Anhydrase Ii Deficiency Syndrome

  • Carbonic Anhydrase Ii Variant

  • Osteopetrosis, Autosomal Recessive, Type 3

  • Carbonic Anhydrase 2
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Hyperchlorhidrosis, Isolated

  • Isolated Hyperchlorhidrosis

  • HYCHL

  • Carbonic Anhydrase Xii Deficiency
Non-Proliferative Fibrocystic Change Of The Breast

  • Non-Proliferative Fibrocystic Change

  • Breast Fibrocystic Change, Non-Proliferative Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01765 CA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01907 Car12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180864 CA12 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CA12 VGNC VGNC:60242
Canis familiaris CA12 VGNC VGNC:38607
Macaca mulatta CA12 VGNC VGNC:70488
Mus musculus CA12 MGD MGI:1923709
Bos taurus CA12 VGNC VGNC:26650
Rattus norvegicus CA12 RGD RGD:1306612
Others CA12 NCBI