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Cat. No.: HY-126699

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Herbimycin C

(Synonyms: Antibiotic TAN 420D)

Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC₅₀s=7.3 and 1.2 μg/mL, respectively).

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CAS No.: 91700-92-4
Formule: C₂₉H₄₀N₂O₉
Masse moléculaire:560.64

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Herbimycin C Chemical Structure

CAS No.: 91700-92-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC₅₀s=7.3 and 1.2 μg/mL, respectively).

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3.01 μM Compound: 2	Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
A-375	IC₅₀	2.43 μM Compound: 2	Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
BGC-823	IC₅₀	3.99 μM Compound: 2	Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
HCT-116	IC₅₀	9.39 μM Compound: 2	Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
MCF7	IC₅₀	5.07 μM Compound: 2	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
SW1990	IC₅₀	8.62 μM Compound: 2	Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]

Chemical Information

CAS No. 91700-92-4
Masse moléculaire 560.64
Formule C₂₉H₄₀N₂O₉
SMILES

CO[C@@]1([H])C(C(C(NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@@H]1C)=O)=C2)=O)=CC2=O
Synonyms

Antibiotic TAN 420D
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shibata, et al. The structure and cytocidal activity of herbimycin C. J. Antibiot. (Tokyo) 39(11), 1630-1633 (1986).

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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