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Cat. No.: HY-153517

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hRVs-IN-1

hRVs-IN-1 (Compound 6g) is a selective anti-hRV viral agent. hRVs-IN-1 inhibits the replication of tested hRV strains with EC₅₀ values of 0.083, 0.078, and 0.015 μM against hRV-B14, hRV-A21, and hRV-A71, respectively. hRVs-IN-1 inhibits the replication of PV3 with an EC₅₀ of 0.063 μM.

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CAS No.: 2104030-01-3
Formule: C₂₀H₂₀N₂O₄S
Masse moléculaire:384.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

hRVs-IN-1 Chemical Structure

CAS No.: 2104030-01-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	CC₅₀	18.1 μM Compound: 6g	Cytotoxicity against human H1HeLa cells assessed as decrease in cell viability after 3 days by MTT assay Cytotoxicity against human H1HeLa cells assessed as decrease in cell viability after 3 days by MTT assay	[PMID: 28581749]
HeLa	CC₅₀	9.6 μM Compound: 6g	Cytotoxicity aganist human HeLa cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity aganist human HeLa cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 28581749]
HeLa	EC₅₀	0.063 μM Compound: 6g	Antiviral activity against Human poliovirus 3 infected in human HeLa cells assessed as protection against virus induced cytopathic effect after 2 days by MTT assay Antiviral activity against Human poliovirus 3 infected in human HeLa cells assessed as protection against virus induced cytopathic effect after 2 days by MTT assay	[PMID: 28581749]

In Vitro

hRVs-IN-1 (3 days) potently inhibits replication of hRV-B14, hRV-A21, and hRV-A71 in H1HeLa cells with EC₅₀ values of 0.083, 0.078, and 0.015 μM, respectively, and high selectivity indices ranging from 220 to 1200^[1].
hRVs-IN-1 (2 days) potently inhibits replication of PV3 in HeLa cells with an EC₅₀ of 0.063 μM and a selectivity index of 150^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2104030-01-3
Masse moléculaire 384.45
Formule C₂₀H₂₀N₂O₄S
SMILES

O=C(OC(C)C)C=1SC=2C=C(OC=3C=CN=C(C3)C(=O)NC)C=CC2C1C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kim J, et al. A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication. J Med Chem. 2017;60(13):5472-5492. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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