IAV-IN-2
IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME).
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- Formule: C22H25N3O5
- Masse moléculaire:411.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
IAV-IN-2 (0.01-10 µM) inhibits IAV A/X‐31 (H3N2) (with IC50 of 4.08 μM), A/WSN/33 (H1N1), A/Udorn/72 (H3N2) and A/NYMC (H3N2) with 97%–100% inhibitory potency[1].
IAV-IN-2 (1-1000 μM) exhibits cytotoxicity in cell A549 with CC50 of 33.9 μM[1].
IAV-IN-2 (10 μM) causes endosomal maturation defect, which disrupts the step-wise priming of the viral core during its endosomal trafficking, disabling the virus to uncoat its capsid and release its genome into the cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:A549
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Concentration:1-1000 μM
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Incubation Time:24 h
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Result:Exhibited cytotoxicity in A549.
Chemical Information
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Masse moléculaire 411.45
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Formule C22H25N3O5
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SMILES
O=C(C1=CC=C(/N=N/N2CCOCC2)C=C1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IAV-IN-2 Related Classifications
HY-158097 Related Classifications
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