Imalumab
Based on 1 Customer Validation
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer.
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- Pureté: 98.37%
- CAS No.: 1430205-07-4
- Masse moléculaire:144.52 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Human IgG1 kappa
Human
MIF
Imalumab specifically binds to oxidized macrophage migration inhibitory factor (oxMIF), interferes with the downstream signaling pathways. Imalumab induces antibody dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), induces cell lysis in human PBMCs with EC50 of 0.7-39.2 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1X106 Jurkat cells with Imalumab (HY-P99262, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1430205-07-4
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Appearance Liquid
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Masse moléculaire 144.52 kDa
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Color Colorless to light yellow
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SMILES
[Imalumab]
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Synonyms
BAX69; Anti-Human MIF Recombinant Antibody
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Bax HJ, et al. Therapeutic targets and new directions for antibodies developed for ovarian cancer. MAbs. 2016 Nov/Dec;8(8):1437-1455. [Content Brief]
[2]. Rossmueller G, et al., Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic. Mol Cancer Ther. 2023 May 4;22(5):555-569. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)