MIF - macrophage migration inhibitory factor Gene

Also Known as GIF; GLIF; MMIF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4282

About MIF

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,894,383-23,895,223 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 221 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues.

Summary

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in Integrin signaling pathways. [provided by RefSeq, Jul 2008]

MIF Products (1)

mRNA	Protein	Name
NM_002415.2	NP_002406.1	macrophage migration inhibitory factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	19602265	GOA
enables cytokine activity	IDA IDA: Inferred from direct assay	12782713	GOA
enables cytokine receptor binding	IDA IDA: Inferred from direct assay	21817065	GOA
enables cytokine receptor binding	IPI IPI: Inferred from physical interaction	17045821	GOA
enables dopachrome isomerase activity	IDA IDA: Inferred from direct assay	17526494	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20534506	GOA
enables phenylpyruvate tautomerase activity	IDA IDA: Inferred from direct assay	16285950	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12681488	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in carboxylic acid metabolic process	IDA IDA: Inferred from direct assay	12782713	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12782713	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	17045821	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12782713	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22952837	GOA
involved in negative regulation of cellular senescence	IDA IDA: Inferred from direct assay	10562313	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	10562313	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	17045821	GOA
involved in negative regulation of macrophage chemotaxis	IDA IDA: Inferred from direct assay	21817065	GOA
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	12782713	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	12782713	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	21817065	GOA
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	17045821	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10562313	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	19602265	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	12782713	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	12782713	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	21817065	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	12782713	GOA
involved in protein homotrimerization	IPI IPI: Inferred from physical interaction	17526494	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	12782713	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24569872	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	12782713	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21817065	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24569872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIF Protein Structure

MIF

0
100
115 a.a.

Protein Preferred Names	Protein Names
macrophage migration inhibitory factor	L-dopachrome isomerase

MIF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MIF	P14174	EGFR	Homo sapiens	P00533	Anti Bait CoIP	26280537
Intra	MIF	P14174	EGFR	Homo sapiens	P00533	Pull Down	26280537
Intra	MIF	P14174	EGFR	Homo sapiens	P00533	Anti Tag CoIP	26280537
Intra	MIF	P14174	HTRA1	Homo sapiens	Q92743	MST	28726057
Intra	MIF	P14174	HTRA1	Homo sapiens	Q92743	Y2H	28726057
Intra	MIF	P14174	MIF	Homo sapiens	P14174	Y2H Prey Pooling	32296183
Intra	MIF	P14174	MIF	Homo sapiens	P14174	Y2H Array	31515488
Intra	MIF	P14174	MIF	Homo sapiens	P14174	Validated Y2H	32296183
Intra	MIF	P14174	COPS5	Homo sapiens	Q92905	Anti Bait CoIP	15757663
Intra	MIF	P14174	COPS5	Homo sapiens	Q92905	SLCA	15757663
Intra	MIF	P14174	MIF	Homo sapiens	P14174	Y2H Array	32296183
Intra	MIF	P14174	MIF	Homo sapiens	P14174	Y2H Array	25416956
Intra	MIF	P14174	MIF	Homo sapiens	P14174	NMR	20534506
Intra	MIF	P14174	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	MIF	P14174	MIF	Homo sapiens	P14174	X-Ray Diffraction	20534506
Intra	MIF	P14174	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	MIF	P14174	BCL2L11	Homo sapiens	O43521-2	Pull Down	18677096
Intra	MIF	P14174	BCL2L11	Homo sapiens	O43521-2	Anti Bait CoIP	18677096

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MIF Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7387	MIF Protein, Human	P14174 (M1-A115)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70288	MIF Protein, Human (His, solution)	P14174 (M1-A115)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70288AF	Animal-Free MIF Protein, Human (His)	P14174 (M1-A115)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700425	MIF Protein, Human (HEK293, hFc)	P14174 (P2-A115)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700513	MIF Protein, Human (N-His, C-Myc)	P14174 (P2-A115)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700792	MIF Protein, Human (HEK293, His)	P14174 (P2-A115)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P70288A	MIF Protein, Human (His)	P14174 (M1-A115)	≥ 95%, as determined by reducing SDS-PAGE.

MIF Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82167	MIF Antibody (YA1912)	WB, IP, FC	Human, Mouse, Rat
HY-P86478	MIF Antibody (YA6170)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Rheumatoid Arthritis, Systemic Juvenile	Rheumatoid Arthritis, Systemic Juvenile, Susceptibility To Juvenile-Onset Still Disease Systemic Juvenile Rheumatoid Arthritis Rheumatoid Arthritis Systemic Juvenile RASJ Systemic Onset Juvenile Chronic Arthritis
Systemic Onset Juvenile Idiopathic Arthritis	Systemic-Onset Juvenile Idiopathic Arthritis Still Disease Systemic Juvenile Idiopathic Arthritis Systemic-Onset Jia Still'S Disease Systemic Onset Juvenile Rheumatoid Arthritis Systemic Polyarthritis Polyarthritis, Systemic Systemic Onset Juvenile Chronic Arthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Nodding Syndrome	Nodding Disease
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Hemosiderosis	Haemosiderosis Iron Overload
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Plasmodium Falciparum Malaria	Falciparum Malaria Malaria, Falciparum Malaria Fever, Subtertian Malignant Tertian Fever Malaria Falciparum Cerebral Malaria Nos Cerebral Malaria
Juvenile Arthritis	JUVAR Arthritis, Juvenile
Angelucci'S Syndrome	Acute Atopic Conjunctivitis Angelucci Syndrome Critical Allergic Conjunctivitis Syndrome Atopic Conjunctivitis Allergic Ophthalmia Spring Ophthalmia Spring Catarrh
Arthus Reaction	Arthus Phenomenon Arthus Type Urticaria
Glomerulonephritis	Bright'S Disease
Macular Holes	Macular Hole
Erythema Nodosum
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Alzheimer Disease 17	AD17 Alzheimer'S Disease 17 Alzheimer Disease 17, Late-Onset Alzheimer Disease 17, Late Onset
Colitis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Acute Apical Periodontitis	Acute Apical Periodontitis Of Pulpal Origin Acute Apical Periodontitis Nos Aap - [Acute Apical Periodontitis]
Bladder Tuberculosis	Tuberculous Cystitis Tuberculosis Of Bladder
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Diabetes Mellitus	Diabetes
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-17009	Iguratimod	Inhibitor	98.49%	Yes

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-121356	Carebastine		99.23%	Phase 3
HY-105077A	Nemifitide diTFA		98.24%	Phase 2
HY-16692	ISO-1	Inhibitor	99.84%	Phase 1

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99262	Imalumab	Inhibitor	98.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (35)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-110063	4-IPP	Inhibitor	99.40%	Unkown
HY-147390	MIF098	Inhibitor	99.99%	Unkown
HY-110095	(±)-CPSI-1306	Antagonist	99.64%	Unkown
HY-130332	Mitomycin A	Inhibitor	98.3%	Unkown
HY-W019710	(E,E)-RGFP966	Inhibitor	99.44%	Unkown
HY-107663A	MIF-1 TFA	Modulator	99.34%	Unkown
HY-148117	MD13		99.96%	Unkown
HY-110084	BTZO-1		99.32%	Unkown
HY-123814	4-CPPC	Inhibitor	98.20%	Unkown
HY-N10096	Epoxyazadiradione		99.24%	Unkown
HY-W164560	RDR 03785	Inhibitor	97.05%	Unkown
HY-149308	MKA031	Inhibitor	98.69%	Unkown
HY-D0039	3-Cyanoumbelliferone		≥98.0%	Unkown
HY-115887	R110	Inhibitor	99.90%	Unkown
HY-RS08445	MIF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12386	S100A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-173624	TE-11	Inhibitor	/	Unkown
HY-107663	MIF-1	Modulator	/	Unkown
HY-115888	MIF2-IN-1	Inhibitor	/	Unkown
HY-123970	ISO-92	Inhibitor	/	Unkown
HY-144190	MIF-IN-1	Inhibitor	/	Unkown
HY-144196	MIF-IN-4 hydrochloride	Inhibitor	/	Unkown
HY-146318	MIF-IN-5	Inhibitor	/	Unkown
HY-146319	MIF-IN-6	Inhibitor	/	Unkown
HY-181912	D-DT/MIF-1-IN-1	Inhibitor	/	Unkown
HY-182935	PAANIB-1	Inhibitor	/	Unkown
HY-P3087	Tyr-W-MIF-1	Modulator	/	Unkown
HY-RS00653	AMH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12385	S100A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W415753	Alaptide		/	Unkown
HY-155466	Boc-MIF-1-Am	Activator	/	Unkown
HY-174842	HTS05585	Inhibitor	/	Unkown
HY-RS16522	Mif Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22953	Mif Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00271	Pareptide monohydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIF	MGD	MGI:96982
Bos taurus	MIF	VGNC	VGNC:49557
Felis catus	MIF	VGNC	VGNC:68257
Rattus norvegicus	MIF	RGD	RGD:621163
Others	MIF	NCBI