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(±)-CPSI-1306 

Cat. No.: HY-110095 Purity: 98.50%
Handling Instructions

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

For research use only. We do not sell to patients.

(±)-CPSI-1306 Chemical Structure

(±)-CPSI-1306 Chemical Structure

CAS No. : 1309793-47-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

IC50 & Target

MIF[1].

In Vivo

Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2227 mL 16.1134 mL 32.2269 mL
5 mM 0.6445 mL 3.2227 mL 6.4454 mL
10 mM 0.3223 mL 1.6113 mL 3.2227 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Six- to 8-wk-old female BALB/c mice and ICR mice are used in the study. Age- and sex-matched ICR mice are deprived of food for 20 h and then injected intraperitoneally with STZ (90 mg/kg). Beginning at 6 h after STZ injection, mice are administered CPSI-1306 (1 or 0.1 mg/kg) or PBS daily in a single oral dose for 30 d[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

310.30

Formula

C₁₅H₁₆F₂N₂O₃

CAS No.

1309793-47-2

SMILES

FC1=C(C=CC(F)=C1)C2=NOC(CC(N3CCOCC3)=O)C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
(±)-CPSI-1306
Cat. No.:
HY-110095
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(±)-CPSI-1306

Cat. No.: HY-110095