Tyr-W-MIF-1
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia.
For research use only. We do not sell to patients.
- CAS No.: 144450-13-5
- Formula: C27H32N6O5
- Molecular Weight:520.58
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Opioid Receptor Isoforms
More
Biological Activity
Tyr-W-MIF-1 (1-10 μM) inhibits the spontaneous firing on LC neurons[1].
Tyr-W-MIF-1 attenuates Morphine (3 μM)-induced down-regulation of both mu and delta receptors in SH-SY5Y human neuroblastoma cells[4].
Tyr-W-MIF-1 (0.3 μM) inhibits the binding of 3H-DAMGO (selective for mu opiate receptors) to rat brain[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tyr-W-MIF-1 (i.t., 0.75 μg) induces analgesia, and is reversed by Naloxone[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats[2]
-
Dosage:200 μg in 5 μL
-
Administration:Intracerebroventricular injection (i.c.v)
-
Result:Prolonged analgesia, measured by latency to remove the tail from a heating element.
Chemical Information
-
CAS No. 144450-13-5
-
Molecular Weight 520.58
-
Formula C27H32N6O5
-
Sequence Shortening
YPWG-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. [Content Brief]
[2]. Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. [Content Brief]
[3]. Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. [Content Brief]
[4]. Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. [Content Brief]
[5]. Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyr-W-MIF-1 Related Classifications
HY-P3087 Related Classifications
Powered by Bioz