JSD26
JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI).
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- CAS No.: 2353515-08-7
- Formule: C18H14N2O2
- Masse moléculaire:290.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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SCoR2 93 nM (IC50) |
JSD26 (120 mg/kg, i.p., once) alleviates symptoms in acute kidney injury (AKI) mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy C57BL/6J mice[1].
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Dosage:20 mg/kg, 40 mg/kg, 80 mg/kg, 120 mg/kg
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Administration:I.p., once
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Result:At the highest dose (120 mg/kg), renal SCoR2 activity was inhibited by 80%.
Did not inhibit renal AKR1B1 activity and inhibited SCoR2 in other organs (liver, lung, heart, spleen), but showed no inhibition in brain tissue, indicating that it cannot cross the blood-brain barrier.
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Animal Model:Male C57BL/6J (9–11 weeks, 25–28 g) were induced with AKI via ischemia-reperfusion (I/R) surgery[1].
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Dosage:120 mg/kg
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Administration:I.p., once
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Result:Renal SCoR2 activity was inhibited by 80%, but SCoR2 protein expression levels remained unchanged.
Serious creatinine and BUN levels were significantly reduced, indicating improved renal function.
Histological analysis (H&E staining) showed reduced tubular damage in the JSD26 treatment group (e.g., reduced tubular dissolution and debris).
PKM2 S-nitrosylation (SNO-PKM2) levels were increased, and PKM2 activity was decreased.
Chemical Information
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CAS No. 2353515-08-7
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Masse moléculaire 290.32
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Formule C18H14N2O2
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SMILES
O=C1NC(C2(C3=C(C4=CC=C(C5CC5)C=C42)C=CC=C3)N1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JSD26 Related Classifications
HY-177415 Related Classifications
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