JX040
JX040 has an antiviral activity against non-polio enteroviruses, while JX040 has a weak antiviral activity against polioviruses.
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- CAS No.: 1089596-75-7
- Formule: C19H17N5OS
- Masse moléculaire:363.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-MK2 | CC50 |
>200 μM
Compound: JX040
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Cytotoxicity against monkey LLC-MK2 cells after 3 to 4 days by crystal violet staining-based spectrophotometric method
Cytotoxicity against monkey LLC-MK2 cells after 3 to 4 days by crystal violet staining-based spectrophotometric method
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[PMID: 29346733] |
| Rhabdomyosarcoma cell | CC50 |
>50 μM
Compound: JX040
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Cytotoxicity against human RD cells incubated for 3 days by neutral red uptake method
Cytotoxicity against human RD cells incubated for 3 days by neutral red uptake method
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[PMID: 34085827] |
Chemical Information
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CAS No. 1089596-75-7
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Masse moléculaire 363.44
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Formule C19H17N5OS
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SMILES
O=C(C1=C2C(N(C(C)C)N=C2)=NC(C3=CC=CS3)=C1)NC4=NC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JX040 Related Classifications
HY-113891 Related Classifications
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