ML338
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy.
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- CAS No.: 1630160-25-6
- Formule: C17H12ClN5OS
- Masse moléculaire:369.83
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli)IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli)
ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC90 of 1 μM. Additionally, ML338 have an IC99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs[1].ML338 (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration[1].ML338 is against the non-replicating M. tuberculosis with IC90 and IC99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC90 and IC99 velues of 62 μM and 62 μM, respectively by CFU[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1630160-25-6
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Masse moléculaire 369.83
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Formule C17H12ClN5OS
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SMILES
ClC1=CC=C(C2=NN=C(SCC3=CN(C4=CC=CC=C4)N=N3)O2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML338 Related Classifications
HY-136348 Related Classifications
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