PARP1/BRD4-IN-3
PARP1/BRD4-IN-3 (compound HF4) is a potent BRD4 and PARP1 inhibitor with IC50 values of 1210, 2019 nM for BRD4, PARP1, respectively. PARP1/BRD4-IN-3 shows antiproliferative activities. PARP1/BRD4-IN-3 induces apoptosis and cell cycle arrest at G0/G1 phase. PARP1/BRD4-IN-3 causes DNA damage and reduces the protein expression of Rad51. PARP1/BRD4-IN-3 shows antitumor efficacy.
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- Formule: C18H17FN2O3S
- Masse moléculaire:360.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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PARP1 2019 nM (IC50) |
BRD4 1210 nM (IC50) |
BRD2 BD2 6831 nM (IC50) |
BRD3 4792 nM (IC50) |
BRD4 BD1 204 nM (IC50) |
BRD4 BD2 801 nM (IC50) |
BRD1 55618 nM (IC50) |
Chemical Information
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Masse moléculaire 360.40
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Formule C18H17FN2O3S
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SMILES
O=S(C1=CC=C(F)C(C)=C1)(NC2=CC3=C(NC(C(CC)=C3)=O)C=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1/BRD4-IN-3 Related Classifications
HY-169170 Related Classifications
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